Puts kids' stuffed animals inside a pillow case, tie a knot in it and wash them in the washing machine.
You can also freshen the animals by placing them in a paper sack with baking soda and shaking them up good.
If the animal is stuffed with natural fibers it should not be immersed in water, but can be wiped off with a soapy cloth, followed by a clean wet cloth.
Make sure the animal doesn't have torn seams before you put it in the washing machine.
Look for plastic parts before tossing a stuffed animal in the dryer.
Make sure the animal doesn't have a "sound box" or other mechanical parts before you put them in the washing machine and dryer.